| #1 | Spartanburg Community College | Spartanburg, SC | ~$2,000/yr (est.) | Rural upstate students wanting schedule flexibility | |
Spartanburg Community College's Practical Nursing diploma stands out for its affordability and regional access, with a net price of $2,405 and median graduate debt of $6,500. The program has expanded to offer day, night, and weekend options at both the Cherokee and Union campuses, doubling capacity to about 100 students annually. While the institution's graduation rate is 28%, this figure reflects all SCC students and not the nursing program specifically. Note the program is currently in candidacy for ACEN accreditation. - Provides training for entry-level nursing under RN or physician direction
- ACEN candidacy ensures quality standards
- Flexible day, night, and weekend class sections available
- Union County campus offers compressed 7.5-week course sequence
- Admission requires TEAS, with higher scores breaking ties for limited seats
- Background check conducted after acceptance, reducing upfront barriers
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| #2 | Florence-Darlington Technical College | Florence, SC | $5,000 – $7,000/yr | Pee Dee region students prioritizing affordability | |
Florence-Darlington Technical College's LPN program is a 16-month, 48-credit diploma that combines classroom and clinical training with regional healthcare partners in the Pee Dee area. With a net price of $2,004 and median debt of $12,250, it is one of the most affordable options in the state. Admission is competitive, requiring TEAS scores and mandatory Career Talk attendance, and the program's first-qualified model favors early, well-prepared applicants. - 16-month diploma with 48 credit hours
- TEAS exam required for admission
- Clinical rotations at hospitals and long-term care sites in Florence-Darlington area
- Mandatory Career Talk attendance for prospective students
- First-qualified admission model rewards early applicants
- Prepares graduates for NCLEX-PN licensure
- Strong pipeline to local employers in the Pee Dee region
- Prerequisite: BIO 112 or BIO 210/211
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| #3 | Orangeburg Calhoun Technical College | Orangeburg, SC | $5,000 – $8,000/yr | Career changers needing accelerated entry option | |
Orangeburg Calhoun Technical College's Practical Nursing program offers both Traditional and FLEX tracks, allowing students with prior coursework to accelerate. With a 94% NCLEX pass rate and 100% job placement in the local area, it provides strong employment outcomes. The net price of $6,186 and median debt of $10,562 keep it accessible, and the 32.3% institutional graduation rate should be considered in context. - 94% NCLEX-PN pass rate
- 100% job placement within Orangeburg and Calhoun counties
- Two program models: Traditional for newcomers, FLEX for those with prior coursework
- Multiple start dates in fall and spring
- Hands-on clinical experiences early in the curriculum
- Prepares students for the PN licensure board examination
- Approved by the South Carolina State Board of Nursing
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| #4 | Central Carolina Technical College | Sumter, SC | $6,000/yr | | |
Central Carolina Technical College's Practical Nursing diploma serves a four-county region (Sumter, Clarendon, Kershaw, Lee) and emphasizes competitive admission based on GPA and test scores. With a net price of $5,571 and median debt under $10,000, it is a budget-friendly pathway. The program is approved by the SC Board of Nursing and is a candidate for ACEN accreditation. - 48-credit diploma program
- Candidate for ACEN accreditation
- Competitive entry based on prerequisite GPA and test scores
- Clinical rotations at regional healthcare partners
- Approved by SC LLR Board of Nursing
- Prepares for NCLEX-PN licensure
- Serves a multi-county area with affordable tuition
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| #5 | Horry-Georgetown Technical College | Conway, SC | ~$4,000/yr (est.) | | |
Horry-Georgetown Technical College's Nursing-PN Diploma is ACEN-accredited and embedded in the coastal Grand Strand healthcare community, with clinical placements in hospitals, clinics, and long-term care. The net price of $4,159 ranks among the lowest, though median graduate debt is $14,250. Admission is first-qualified, favoring early applicants who meet the 2.5 GPA and TEAS requirements. - ACEN-accredited program
- 48 total credit hours
- TEAS exam required for admission
- First-qualified admission model with limited seats
- Clinical training across hospitals and long-term care in Horry and Georgetown counties
- Curriculum covers medical-surgical, maternal/infant, and pharmacology
- Graduates eligible for NCLEX-PN licensure
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| #6 | York Technical College | Rock Hill, SC | ~$6,000/yr (est.) | | |
York Technical College delivers its Practical Nursing program at the Chester Center, with clinical rotations spanning three counties, making it accessible to rural communities. The net price is $5,931 and median debt is just $7,000, among the lowest in the state. Admission uses a first-qualified, first-served waitlist, and TEAS or placement tests can be used for entry. - ACEN-accredited diploma program
- Based at the Chester campus serving York, Chester, and Lancaster counties
- Limited enrollment with first-qualified, first-served waitlist
- TEAS or placement test accepted for admission
- Clinical training in hospitals and community agencies across three counties
- 2.0 GPA minimum requirement
- Prepares students for NCLEX-PN exam
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| #7 | Northeastern Technical College | Cheraw, SC | $7,000/yr (net price) | | |
Northeastern Technical College's Applied Science - Practical Nursing program can be completed in two semesters and one summer term, making it one of the quicker routes to LPN licensure in the state. With a net price of $6,913, it is affordable, though institutional graduation rate is just 21%. Competitive admissions require TEAS scores and a two-attempt limit for nursing programs. - Fast-track: complete in two semesters and one summer term
- 48 total credit hours
- TEAS exam required; competitive admissions process
- Two-attempt limit for nursing program applications
- Seamless LPN-to-ADN transition pathway available
- Clinical experience integrated throughout the curriculum
- Prepares for NCLEX-PN licensure
- Criminal background check and possible drug testing required
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| #8 | Midlands Technical College | West Columbia, SC | $5,000 – $15,000/yr | | |
Midlands Technical College's Practical Nursing program offers three annual start dates and boasts a 90% licensure pass rate with 96% job placement. The net price of $4,647 is notably low, though the institutional graduation rate of 18% is not program-specific. The program features a state-of-the-art simulation lab and strong clinical partnerships in the Columbia area. - ACEN-accredited with three start dates per year (fall, spring, summer)
- 44-credit diploma program; total tuition estimated at $8,976
- 90% NCLEX pass rate and 96% job placement rate
- State-of-the-art simulation lab for hands-on practice
- Competitive admission based on prerequisite GPA and test scores
- LPN-to-ADN bridge option for career advancement
- Clinical rotations at Columbia-area healthcare facilities
- Background check, drug screen, and immunizations required
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| #9 | Williamsburg Technical College | Kingstree, SC | ~$10,000/yr (est.) | | |
Williamsburg Technical College's 40-week Diploma in Health Science Practical Nursing is an intensive, one-year option for rural students. The net price of $9,887 is higher than some public colleges, and the 15% institutional graduation rate is one of the lowest in the ranking. Applicants must achieve a TEAS score of 60 or above and maintain a 2.0 GPA. - Intensive 40-week program completed in one academic year
- 48 credit hours required
- TEAS exam score of 60 or higher for admission
- Minimum 2.0 GPA requirement
- Campus-based learning with hands-on clinical practice
- Teamwork under RN supervision emphasized
- Prepares students for NCLEX-PN examination
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| #10 | Piedmont Technical College | Greenwood, SC | $10,000 – $15,000/yr | | |
Piedmont Technical College's Practical Nursing D.A.S. program features a highly selective 32-student cohort with a 3.0 minimum GPA requirement, among the highest in South Carolina. The net price of $11,366 and median debt of $15,000 are above average, but the 33% institutional graduation rate is relatively solid. Clinicals are offered at both Greenwood and Laurens campuses, serving a wide area. - Three-semester, 46-credit diploma
- Competitive admission limited to 32 students
- Minimum 3.0 prerequisite GPA required
- TEAS exam scores factored into admission decisions
- Clinical experiences at Greenwood or Laurens campuses
- Approved by South Carolina Board of Nursing
- LPN-to-ADN transition pathway available
- Fall and spring start dates
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| #11 | Tri-County Technical College | Pendleton, SC | $10,000 – $15,000/yr | | |
Tri-County Technical College boasts the highest institutional graduation rate in this ranking at 42%, a notable overall metric. The Practical Nursing program is offered at the Easley campus with both day and evening classes, and a net price of $14,670 against median debt of $9,000. Its curriculum emphasizes serving others and solving complex problems in healthcare settings. - Diploma program offered at the Easley campus
- Both day and evening class schedules available
- Face-to-face instruction with hands-on clinical training
- Financial aid available for eligible students
- Curriculum covers medical-surgical, pharmacology, maternal-child health
- Prepares graduates for NCLEX-PN licensure
- Focus on helping and serving diverse patient populations
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| #12 | Technical College of the Lowcountry | Beaufort, SC | $10,000 – $15,000/yr | | |
Technical College of the Lowcountry's Practical Nursing diploma is a fast-track, one-year program with a 100% NCLEX pass rate over five consecutive years and ACEN accreditation. The net price of $14,724 and median debt of $10,000 place it in the mid-range. Classes are held at Beaufort and New River campuses, and many students attend tuition-free through SC Lottery Tuition Assistance. - ACEN-accredited one-year diploma (42 credits)
- 100% NCLEX-PN pass rate for five consecutive years
- Full-time day classes at Beaufort and New River campuses
- SC Lottery Tuition Assistance makes attendance nearly free for many
- Total program tuition estimated at $8,988
- Fall start only; competitive admission
- National background check and drug screen required
- Strong pipeline to Lowcountry healthcare employers
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| #13 | Galen Health Institutes-Myrtle Beach | Myrtle Beach, SC | $26,000/yr (net price) | | |
Galen Health Institutes-Myrtle Beach, a private nursing college, offers a Practical/Vocational Nursing program that can be completed in 12 months full-time or 21 months part-time. While the net price of $25,662 and median debt of $24,166 are significantly higher than public options, graduates report 10-year median earnings of $61,480, the highest in the ranking. The program has four start dates annually, providing flexibility. - 12 months full-time or 21 months part-time completion
- Four start dates per year for flexible enrollment
- On-campus classes with hands-on clinical training
- Prepares students for NCLEX-PN licensure
- Supportive learning environment designed for new nursing students
- Curriculum blends theory and practical skills
- Private institution with higher tuition but strong earnings outcomes
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| #14 | Denmark Technical College | Denmark, SC | $15,000 – $20,000/yr | | |
Denmark Technical College, a historically Black college, offers a Diploma in Practical Nursing with a net price of $19,156 and median debt of $15,250. The institutional graduation rate is just 12.5%, the lowest in this ranking. Admission requires a 2.5 GPA, Accuplacer Next Generation, and ATI TEAS scores, along with prerequisite coursework. - Diploma program at a historically Black college
- Campus-based with hands-on clinical experience
- Admission requires 2.5 GPA, Accuplacer, and TEAS assessments
- Curriculum includes anatomy, pharmacology, and medical-surgical nursing
- Financial aid and scholarships available to eligible students
- Prepares for a practical nursing career in diverse settings
- Serves rural students in the Bamberg-Barnwell region
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