| #1 | Mitchell Technical College | Mitchell, SD | $10,000 – $15,000/yr (est.) | Working LPNs needing minimal campus time | |
Mitchell Technical College stands out as an efficient LPN-to-RN bridge that lets working licensed practical nurses complete most theory and general education online while doing one clinical day per week around Mitchell. The associate degree track is approved by the South Dakota Board of Nursing and leads to NCLEX-RN eligibility. It is a fit for LPNs who need to keep working while moving into registered nursing. Military benefits - South Dakota Board of Nursing approved
- 2.5 GPA minimum required
- Online theory and general education courses
- One clinical day per week in Mitchell area
- 600 hours paid LPN work required
- Prepares for NCLEX-RN
- AAS degree awarded
- Military benefits and financial aid available
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| #2 | Lake Area Technical College | Watertown, SD | ~$16,000/yr (est.) | Budget-conscious students seeking hybrid flexibility | |
Lake Area Technical College offers an 11-month registered nursing year that follows an LPN year or prerequisite coursework, with a hybrid E-Degree option that keeps most learning online. The program requires 41 credits in the RN year and includes 449 clinical hours, and credits transfer to the university system for students who later pursue a BSN. Its low tuition and structured format make it one of the most affordable ways to enter nursing in South Dakota. - 41 total credit hours in RN year
- Starts fall
- 449 clinical hours included
- Prerequisite courses required
- Hybrid E-Degree format available
- 20 credits granted for LPN license
- Courses transfer to university system
- 11-month program duration
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| #3 | Augustana University | Sioux Falls, SD | $20,000 – $25,000/yr (est.) | Holistic-focused BSN students in Sioux Falls | |
Augustana University's BSN is anchored in Sioux Falls, giving nursing students weekly clinical experience inside the region's largest healthcare systems. The program is distinguished by its holistic nursing endorsement and includes advanced simulation, leadership practicums, and study away options in Costa Rica, Norway, and Greece. It is a strong four-year route for students who want a residential campus experience and immediate exposure to Sanford and Avera clinical environments. CCNE accredited - CCNE accredited
- Weekly clinical experiences in Sioux Falls
- Holistic nursing program endorsement
- Advanced simulation center
- Study away in Costa Rica, Norway, Greece
- Clinical partnerships with Sanford and Avera
- Sigma Theta Tau honor society
- Leadership practicums
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| #4 | South Dakota State University | Brookings, SD | $15,000 – $20,000/yr (est.) | | |
South Dakota State University delivers a public BSN with study locations in Brookings, Rapid City, and Sioux Falls and an online pathway, giving students flexibility across the state. The curriculum covers nursing major courses plus communication and sciences, and it prepares graduates for hospital and nonhospital practice, with alumni employed by major regional systems. It is a strong pick for South Dakota residents who want a public university BSN with broad career options. - Hospital and nonhospital practice settings
- Campus locations in Brookings and Sioux Falls
- Student Nurses Association available
- Critical thinking and ethical decision-making emphasis
- Suggested Health Science minor
- Prepares for advanced practice nursing pathways
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| #5 | Southeast Technical College | Sioux Falls, SD | $15,000 – $20,000/yr (est.) | | |
Southeast Technical College in Sioux Falls offers an ACEN-accredited registered nurse program with fall, spring, and summer starts, including a part-time option and a streamlined LPN-to-RN track for licensed practical nurses with 750 hours of experience. The program emphasizes clinical placements in hospitals, nursing homes, and clinics, and transfer agreements make it easy to continue toward a BSN later. It is a practical, flexible route for students in the Sioux Falls area who want a shorter associate degree path. - ACEN accredited
- $282 per credit
- Part-time schedule available
- Starts fall, spring, or summer
- LPN-to-RN track available
- Transfer agreements to BSN
- Build Dakota Scholarship eligible
- Student Nursing Organization
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| #6 | University of South Dakota | Vermillion, SD | ~$20,000/yr (est.) | | |
The University of South Dakota offers a CCNE-accredited BSN on its Vermillion and Sioux Falls campuses, with clinical experiences each semester in urban and rural hospitals. Students train in simulation labs, can pursue undergraduate research and service learning in Guatemala, and may qualify for ROTC scholarships. This public flagship route is a strong fit for South Dakota residents seeking a research-oriented BSN with a low student-to-faculty ratio. CCNE accredited - CCNE accredited
- Entrance exam required, HESI
- Prerequisite courses required
- $0 application fee
- Low student-to-faculty ratio
- Clinical experiences each semester
- ROTC scholarships available
- Service learning in Guatemala
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| #7 | University of Sioux Falls | Sioux Falls, SD | $21,000/yr (est. net price) | | |
The University of Sioux Falls combines a traditional BSN with an accelerated BSN option for students who already hold a degree or need a fast track. The program reports strong NCLEX pass rates and places students in high-volume Sioux Falls health systems from the first semester, using simulation technology and a nursing curriculum grounded in Christian values. It is a notable private option for students who want a cohort-based, clinically intense experience. CCNE accredited - CCNE accredited
- 97% licensure pass rate
- Clinical experience from first semester
- Simulation technology in training
- Christian values emphasized
- Strong Sioux Falls health system partnerships
CCNE accredited - 4-semester program
- Rolling admissions
- Starts January each year
- Three professional references required
- Second-degree and first-degree options
- Cohort-based structure
- Prerequisite courses required
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| #8 | Western Dakota Technical College | Rapid City, SD | ~$13,000/yr (est.) | | |
Western Dakota Technical College in Rapid City serves western South Dakota with an LPN-to-RN 1+1 bridge that awards an Associate of Applied Science. The program includes an on-campus simulation center, flexible clinical shifts that mirror hospital scheduling, and Build Dakota Scholarship eligibility for qualifying students. It is a practical route for LPNs in the Black Hills region who want to stay local while becoming registered nurses. - ACEN accredited
- Entrance exam required, ACT or SAT
- Two start dates per year
- LPN to RN 1+1 bridge track
- Build Dakota Scholarship covers tuition
- On-campus simulation center
- Clinical shifts evenings, nights, weekends
- Selective admissions process
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| #9 | Dakota Wesleyan University | Mitchell, SD | $15,000 – $20,000/yr (est.) | | |
Dakota Wesleyan University offers both a BSN on its Mitchell campus and an A.S. in Nursing hybrid pathway located at Monument Health in Rapid City. The BSN emphasizes high-tech simulation labs, rural clinical opportunities, and an Avera Achieve sponsorship, while the ASN is a 24-month, 72-credit hybrid option with no healthcare experience required. This dual pathway makes DWU a flexible private choice for students in central and western South Dakota. CCNE accredited - CCNE accredited
- 100% job placement rate
- High-tech simulation labs
- Clinical partnerships with hospitals
- Avera Achieve sponsorship program
- Rural clinical opportunities
- Pinning ceremony tradition
ACEN accredited - ACEN accredited
- $28,800 total program tuition
- $400 per credit
- 24-month program
- 72 total credit hours
- Hybrid learning format
- Located at Monument Health in Rapid City
- Priority admission for 3.0 GPA
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| #10 | Mount Marty University | Yankton, SD | ~$22,000/yr (est.) | | |
Mount Marty University's BSN in Yankton provides hands-on clinical experience from the start, with specialties across pediatrics, maternity, medical-surgical, critical care, and community health. The CCNE-accredited program is grounded in Catholic Benedictine values and offers a direct entry path to the university's Doctor of Nurse Anesthesia Practice program for exceptional students. It is a fit for students in southeastern South Dakota who want a faith-based, clinically focused four-year BSN. CCNE accredited - CCNE accredited
- Hands-on clinicals from day one
- Possible job offer before graduation
- Specialties in pediatrics, maternity, med-surg
- Direct entry to DNAP program
- Catholic Benedictine values
- On-campus in Yankton
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